Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-α
نویسندگان
چکیده
منابع مشابه
The effect of intrahippocampal injection of diarylpropionitrile, a selective estrogen receptor-beta agonist, on passive avoidance learning
Introduction: Neurohormones like testosterone and estradiol have an important role in learning and memory. The hippocampus is essentially involved in learning and memory, and is known to be a target for estradiol actions. Estrogen receptors (ERs) are highly expressed in CA1 of rat hippocampus, and mediate the effects of estrogen on learning and memory. Estradiol receptor belong to a family ...
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Natural estrogens modulate the activity of target cells by binding at least two intranuclear receptors. ERα and ERβ belong to a large family of structurally related transcription factors that are well conserved from the evolutionary and functional points of view. The considerable progress made recently in comprehending ER structure (figs. 6–1 and 6–2) and mechanism of action (fig. 6–2) provides...
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Reproductive function requires timely secretion of gonadotropin-releasing hormone, which is controlled by a complex excitatory/inhibitory network influenced by sex steroids. Kiss1 neurons are fundamental players in this network, but it is currently unclear whether different conditions of circulating sex steroids directly alter Kiss1 neuronal activity. Here, we show that Kiss1 neurons in the ant...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2021
ISSN: 2227-9059
DOI: 10.3390/biomedicines9060681